Oramorph oral solution 500ml

What ORAMORPH Concentrated contains

Each ml contains 20 mg of morphine sulfate as the active ingredient Oramorph oral solution 500ml
The other ingredients are disodium edetate, sodium benzoate (E211), citric acid, amaranth (E123) and purified water

How Oramorph works

Oramorph-6-glucuronide is responsible for approximately 85% of the response observed by morphine administration. Oramorph and its metabolites act as agonists of the mu and kappa opioid receptors. The mu-opioid receptor is integral to morphine’s effects on the ventral tegmental area of the brain. Oramorph’s activation of the reward pathway is mediated by agonism of the delta-opioid receptor in the nucleus accumbens, while modification of the respiratory system and addiction disorder are mediated by agonism of the mu-opioid receptor.

Dosage

Oral-Moderate to severe pain:5-20 mg 4 hrly. Extended-release: 5-20 mg 12 hrly. Dosage is dependent on the severity of pain.

Intraspinal-Moderate to severe pain:Initially, 5 mg epidural inj; after 1 hr, additional doses of 1-2 mg may be given up to a total dose of 10 mg/24 hr if pain relief is unsatisfactory. A dose of 20-30 mg daily may be required in some patients. Liposomal inj: 10-20 mg depending on the type of surgery.

Intrathecal-Moderate to severe pain: 0.2-1 mg once daily or 1-10 mg daily for patients with opioid tolerance. Some patients may require a dose of up to 20 mg daily.Oramorph oral solution 500ml

Intravenous-Acute pulmonary oedema: is oramorph a controlled drug

• Adult: 5-10 mg via slow inj at 2 mg/min. is oramorph a controlled drug
• Elderly: Half of the usual adult dose.

Intravenous-

Pain associated with myocardial infarction:

• Adult: 5-10 mg at 1-2 mg/min followed by a further 5-10 mg as necessary.
• Elderly: Half of the usual adult dose.

Parenteral-

• Moderate to severe pain:5-20 mg; 2.5-10 mg via slow IV inj over 4-5 min with patient in recumbent position or a starting dose of 1-2 mg/hr via continuous IV infusion (max: 100 mg/day; 4 g/day in cancer patients). Doses may be adjusted according to severity of pain and patient’s response.
• Premedication in surgery:Up to 10 mg, given 60-90 min before operation.

May be taken with or without food. May be taken with meals to reduce GI discomfort